For Health Professionals

  • Aloe Barbadensis

Aloe vera gel is obtained from the mucilage in the center of the leaf. It is the main ingredient used in commercial skin products and wound repair products for centuries. Aloe vera gel contains Vitamins A, B, C, E, enzymes, polysaccharides, amino acids, sugars, and minerals. Glycoproteins obtained from A.Vera gel were found to be effective in repair by cell proliferation and migration.

Skin wound healing and phytomedicine: a review.
Skin Pharmacol Physiol. 2014;27(6):303-10. doi: 10.1159/000357477. Epub 2014 Jun 27
Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A

A.vera leaf extract, which is rich in polysaccharides, is frequently used for burns, sunburns, wounds and skin inflammations. In a randomized study, lyophilized A.vera extract was studied on 20 volunteers and a significant increase was observed in the moistening of the skin after 2 weeks. However, there was no significant change in TEWL.

Dermocosmetics for dry skin: a new role for botanical extracts
Skin Pharmacol Physiol. 2011;24(6):289-93. doi: 10.1159/000329214. Epub 2011 Jun 25
Casetti F, Wölfle U, Gehring W, Schempp CM

A.vera has traditionally been used for wounds, burns, insect stings and skin inflammations for centuries. It has antioxidant, anti-inflammatory, antimicrobial and immunomodulatory effects. The mamose-6 phosphate and acemannan in a. vera supports the epithelization for effective wound repair and supports collagen synthesis. A.vera is used for its wound repairing properties.

Naturally derived biofunctional nanofibrous scaffold for skin tissue regeneration
Int J Biol Macromol. 2014 Jul;68:135-43. doi: 10.1016/j.ijbiomac.2014.04.031. Epub 2014 Apr 24
Suganya S, Venugopal J, Ramakrishna S, Lakshmi BS, Dev VR

UV radiation reduces immunity to infections along with many other damages. Vitamin C, Vitamin E, flavonoids, phenolic acids fight with free radicals that cause negative changes in the skin. Therefore, the complex structures of the plants rather than the individual substances have a higher protective effect on the skin. A. vera gel revitalizes the skin and promotes the formation of new cells.

Potential of herbs in skin protection from ultraviolet radiation
Pharmacogn Rev. 2011 Jul;5(10):164-73. doi: 10.4103/0973-7847.91114
Korac RR, Khambholja KM

14 kDa Aloe protein was isolated using DEAE-cellulose and CM-cellulose column with ion exchange chromatography on aloe vera leaf gel. Purified Aloe protein showed antifungal activity against Candida paraprilosis, Candida crusei, and Candida albicans. Additionally, the purified Aloe protein showed anti-inflammatory action with 84% and 73% inhibition against pure lipoxygenase and cyclooxygenase-2. This Aloe protein is a new protein that shows antifungal and anti-inflammatory effects and can be used for medical purposes.

Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel
Int J Biol Macromol. 2011 Jan 1;48(1):38-43. doi: 10.1016/j.ijbiomac.2010.09.010. Epub 2010 Oct 1
Das S, Mishra B, Gill K, Ashraf MS, Singh AK, Sinha M, Sharma S, Xess I, Dalal K, Singh TP, Dey S

Aloe vera gel shows anti-inflammatory, repairing, moisturizing, antibacterial, antifungal and antiviral effects.

The Role of Functional Foods in Cutaneous Anti-aging
J Lifestyle Med. 2014 Mar;4(1):8-16. doi: 10.15280/jlm.2014.4.1.8. Epub 2014 Mar 31
Cho S

A. vera leaf extract is rich in catechin, sinapic acid and quersitrin. The extracts of the leaf also show antioxidant activity and activity against microbial strains. Phenolic compounds in the plant also prevent the diseases due to oxidative stress. There are many chemical compounds such as tannin, saponin, flavonoid, steroid, terpenoid in A.vera leaf and gel. As the phenolic compounds increase, the antioxidant effects also increase.

Phenolic constituents, antioxidant and preliminary antimycoplasmic activities of leaf skin and flowers of Aloe vera (L.) Burm. f. (syn. A. barbadensis Mill.) from the Canary Islands (Spain).
Molecules. 2013 Apr 26;18(5):4942-54. doi: 10.3390/molecules18054942
López A, de Tangil MS, Vega-Orellana O, Ramírez AS, Rico M

The claims in the studies for Aloe vera are as follows:

Aloe vera softens the skin, beta the bisabolol obtained from Chamomile has an anti-inflammatory and antibacterial effect, Calendula oil has a soothing, softening and cells renewing effect, essential fatty acids such as linoleic-linolenic smooth, moisturize and protects the skin, Panthenol moisturizes and soothes the skin.

Efficacy and safety of innovative cosmeceuticals
Clin Dermatol. 2008 Jul-Aug;26(4):367-74. doi: 10.1016/j.clindermatol.2008.01.013
Gao XH, Zhang L, Wei H, Chen HD